Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones.
نویسندگان
چکیده
Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).
منابع مشابه
Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones.
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ورودعنوان ژورنال:
- Chemical communications
دوره 36 شماره
صفحات -
تاریخ انتشار 2008